Efficacy of Vedolizumab Induction and Maintenance Therapy in Patients With Ulcerative Colitis, Regardless of Prior Exposure to Tumor Necrosis Factor Antagonists
نویسندگان
چکیده
منابع مشابه
Vedolizumab as induction and maintenance therapy for ulcerative colitis.
BACKGROUND Gut-selective blockade of lymphocyte trafficking by vedolizumab may constitute effective treatment for ulcerative colitis. METHODS We conducted two integrated randomized, double-blind, placebo-controlled trials of vedolizumab in patients with active disease. In the trial of induction therapy, 374 patients (cohort 1) received vedolizumab (at a dose of 300 mg) or placebo intravenousl...
متن کاملInduction and maintenance therapy with vedolizumab, a novel biologic therapy for ulcerative colitis.
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) characterized by inflammation of the mucosal layer of the colon. The resulting disease includes episodes of recurrent rectal bleeding, increased stool frequency and urgency, abdominal cramps and pain, and systemic symptoms (such as fever, anemia, and weight loss).1 Historical studies have estimated that approximately half of ...
متن کاملa comparison of teachers and supervisors, with respect to teacher efficacy and reflection
supervisors play an undeniable role in training teachers, before starting their professional experience by preparing them, at the initial years of their teaching by checking their work within the proper framework, and later on during their teaching by assessing their progress. but surprisingly, exploring their attributes, professional demands, and qualifications has remained a neglected theme i...
15 صفحه اولDysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy
AIM To study the innate immune function in ulcerative colitis (UC) patients who fail to respond to anti-tumor necrosis factor (TNF) therapy. METHODS Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell (PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF th...
متن کاملInfliximab for induction and maintenance therapy for ulcerative colitis.
BACKGROUND Infliximab, a chimeric monoclonal antibody directed against tumor necrosis factor alpha, is an established treatment for Crohn's disease but not ulcerative colitis. METHODS Two randomized, double-blind, placebo-controlled studies--the Active Ulcerative Colitis Trials 1 and 2 (ACT 1 and ACT 2, respectively)--evaluated the efficacy of infliximab for induction and maintenance therapy ...
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ژورنال
عنوان ژورنال: Clinical Gastroenterology and Hepatology
سال: 2017
ISSN: 1542-3565
DOI: 10.1016/j.cgh.2016.08.044